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KMID : 0043319870100020069
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Archives of Pharmacal Research
1987 Volume.10 No. 2 p.69 ~ p.74
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The Interaction of Zipeprol with beta-Cyclodextrin
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Kim CK
Choi HG
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Abstract
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The characteristics of zipeprol-beta-cyclodextrin system were studied by circular dichroism, competitive UV method and dialysis method. In this experiment, binding constants by competitive UV method, circular dichroism and dialysis method were 155M-1, 187M-1(+/- 5%) and 315M-1, respectively. It shows that zipeprol forms 1:1 complex with beta-cyclodextrin by circular dichroism and 1:2 by dialysis method. pH profile shows that binding force seems to be a hydrophobic interaction. It is suggested that benzene ring be accomodated in the cavity of beta-cyclodextrin.
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